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Proline-rich 12
Proline-rich 12 (PRR12) is a protein of unknown function encoded by the gene ''PRR12''.
== Gene ==
The ''Homo sapiens'' ''PRR12'' gene is 34,785 base pairs long, contains 14 exons, and is located on chromosome 19 at 19q13.33.〔(【引用サイトリンク】title=PRR12 proline rich 12 [Homo sapiens (human)] - Gene - NCBI )〕 Known aliases for PRR12 include “proline rich 12” and KIAA1205.〔(【引用サイトリンク】title=PRR12 Gene - GeneCards | PRR12 Protein | PRR12 Antibody )〕 Within its gene neighborhood, ''PRR12'' is flanked by ''PRRG2'' and ''SCAF1'' on the sense strand and ''RRAS'' and ''NOSIP'' on the antisense strand.〔(【引用サイトリンク】title=PRR12 )〕 Nitric oxide synthase interacting protein, NOSIP, regulates the activity and localization of nitric oxide synthase (endothelial and neuronal), controlling nitric oxide production.〔(【引用サイトリンク】title=NOSIP )〕 Proline rich Gla, PRRG2, has a Gla domain which binds hyaluronan and is associated with proteins present in the ''extracellular matrix'' involved with cell adhesion and cell migration.〔(【引用サイトリンク】title=PRRG2 )〕〔(【引用サイトリンク】title=GLA )〕 Ras-related protein R-Ras, RRAS, belongs to the Ras family and is involved in the organization of actin filaments within the cytoskeleton. SR-Related CTD-Associated 〔(【引用サイトリンク】title=RRAS )〕 Factor 1, SCAF1, is thought to be involved in the splicing of precursor mRNA.〔(【引用サイトリンク】title=SCAF1 )〕
Promoter
The promoter region of PRR12 was predicted using ElDorado at Genomatix. The region starts at position 50094408 and ends at 50095013 of chromosome 19. This promoter set is conserved in the macaque, mouse, rat, horse, cow, pig, dog and zebrafish. No recognizable TATA box, B recognition element (BRE), or CAAT box was found upstream of the predicted transcription start region. Because no clear TATA box was found, it is possible that PRR12 is regulated by a TATA-less promoter containing a downstream promoter element (DPE). However, the predicted DPE is only 15bp downstream of the transcription start region instead of the typical +25 to +32 base pairs. More research will be required to expand the 5’ UTR of the PRR12 transcript in order to confirm where the correct promoter region is located.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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